1.52.0 Debian Bullseye matrix.org repo, HS hacklab.fi
Upgrading workerized synapse to 1.52.0 and synapse won't start, nothing on logs either so very early fail at least without debug logs enabled. I emergency downgraded our HS to 1.51.0 and it started right up again.
While I promised to provide strace too on #synapse:matrix.org, I did promise it later when I can afford to halt our ~100 user homeserver. However there is few others who experienced similar isue, with venv pip installation too, and culplrit is likely needing to have also updated treq package alongside new twist.
Our issue seems having originated from an incompatibility between twisted 22.1.0 and treq which was too old but did not get pulled in as a dependency during pip --upgrade.
Manually upgrading treq and twisted to 22.1.0 has fixed the issue for us.
Related: RedHat Bug 1953535 - ImportError: cannot import name '_PY3' from 'twisted.python.compat'
So there is very likely rootcause there.
I did make issue now as early as possible for all to know, will fill strace later if not confirmed before.