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Venkatesh-99/README.md

Hi, I'm Venkatesh — Bioinformatician | Genomics Researcher | Aspiring PhD Candidate

I hold a Master's in Technology in Bioinformatics and currently work as a Bioinformatician in the Department of Clinical Microbiology at Christian Medical College, Vellore.
My research sits at the intersection of clinical microbiology, pathogen genomics, and machine learning. I specialize in large-scale bacterial genome analysis, focusing on antimicrobial resistance (AMR), virulence profiling, and host-pathogen interactions.


What I’m Currently Working On

  • Hypervirulent E. coli classification using whole-genome sequencing (WGS), clustering, and expert-guided labeling.
  • Bacterial WGS pipelines with Nextflow for automated analysis.
  • Helicobacter pylori disease classification using machine learning, integrating phylogeographic, genomic, and host metadata (age, sex, location).
  • SNP mining in clinically relevant genes and preparing ML-ready feature sets from variant data (VCFs).

Interests

  • Machine learning in microbial genomics
  • Genomic epidemiology and pathogen surveillance
  • AMR and virulence gene detection in large datasets
  • Developing scalable and reproducible pipelines for pathogen analysis

Tools & Technologies I Use

Python R Snakemake Bash Nextflow


Machine Learning Experience

  • Feature engineering using:
    • Z-curve parameters
    • Trinucleotide frequencies
    • SNP effect annotations
  • Model building with Logistic Regression, Random Forests, and SVM
  • SHAP-based feature interpretation for gastric cancer classification

Future Plans

  • Publish pipelines and notebooks used in ongoing clinical microbiology research
  • Collaborate on open-source microbial genomics projects
  • Secure a fully funded PhD position in computational biology
  • Contribute to open data initiatives for AMR and virulence gene tracking

Let's Connect

Feel free to reach out if you share similar interests or are working in microbial genomics!

Pinned Loading

  1. HP_ML HP_ML Public

    A machine learning pipeline for gastric cancer classification from Helicobacter pylori infected patients

    Jupyter Notebook

  2. Microbiome-Visualization-Toolkit-R-Scripts-for-Taxa-Analysis Microbiome-Visualization-Toolkit-R-Scripts-for-Taxa-Analysis Public

    This repository contains R scripts to create interactive plots to visualize microbiome taxa

    R 1

  3. pybioinfo-utils pybioinfo-utils Public

    Python 1