Although TIFF string tags are only supposed to contain 7-bit ASCII characters, many tools write values in UTF-8 or other encodings that aren't 7-bit clean. OME-TIFF/BioFormats is one such tool, where the XML stored in the ImageDescription tag is explicitly encoded as UTF-8. On Python 3, pytiff.Tiff._read_ascii raises a UnicodeDecodeError upon reading such values. On Python 2, where the treatment of string encoding/decoding isn't as rigorous, the problem is effectively ignored.
Would you accept a patch to fix this? I think the simplest approach is to always decode strings as UTF-8, perhaps only under Python 3. This actually mirrors the way _set_tag already performs UTF-8 string encoding, only under Python 3. I would also be willing to implement a more flexible approach with a user-controlled encoding if you think that's a better option.