diff --git a/requirements-common.txt b/requirements-common.txt
index b7c94cbdba8b..07c925cdb92c 100644
--- a/requirements-common.txt
+++ b/requirements-common.txt
@@ -19,7 +19,7 @@ prometheus-fastapi-instrumentator >= 7.0.0
 tiktoken >= 0.6.0  # Required for DBRX tokenizer
 lm-format-enforcer >= 0.10.9, < 0.11
 outlines == 0.1.11
-lark == 1.2.2 
+lark == 1.2.2
 xgrammar == 0.1.11; platform_machine == "x86_64"
 typing_extensions >= 4.10
 filelock >= 3.16.1 # need to contain https://github.com/tox-dev/filelock/pull/317
@@ -36,3 +36,4 @@ einops # Required for Qwen2-VL.
 compressed-tensors == 0.9.1 # required for compressed-tensors
 depyf==0.18.0 # required for profiling and debugging with compilation config
 cloudpickle # allows pickling lambda functions in model_executor/models/registry.py
+watchfiles # required for http server to monitor the updates of TLS files
diff --git a/tests/entrypoints/test_ssl_cert_refresher.py b/tests/entrypoints/test_ssl_cert_refresher.py
new file mode 100644
index 000000000000..23ce7a679f3e
--- /dev/null
+++ b/tests/entrypoints/test_ssl_cert_refresher.py
@@ -0,0 +1,72 @@
+# SPDX-License-Identifier: Apache-2.0
+import asyncio
+import tempfile
+from pathlib import Path
+from ssl import SSLContext
+
+import pytest
+
+from vllm.entrypoints.ssl import SSLCertRefresher
+
+
+class MockSSLContext(SSLContext):
+
+    def __init__(self):
+        self.load_cert_chain_count = 0
+        self.load_ca_count = 0
+
+    def load_cert_chain(
+        self,
+        certfile,
+        keyfile=None,
+        password=None,
+    ):
+        self.load_cert_chain_count += 1
+
+    def load_verify_locations(
+        self,
+        cafile=None,
+        capath=None,
+        cadata=None,
+    ):
+        self.load_ca_count += 1
+
+
+def create_file() -> str:
+    with tempfile.NamedTemporaryFile(dir='/tmp', delete=False) as f:
+        return f.name
+
+
+def touch_file(path: str) -> None:
+    Path(path).touch()
+
+
+@pytest.mark.asyncio
+async def test_ssl_refresher():
+    ssl_context = MockSSLContext()
+    key_path = create_file()
+    cert_path = create_file()
+    ca_path = create_file()
+    ssl_refresher = SSLCertRefresher(ssl_context, key_path, cert_path, ca_path)
+    await asyncio.sleep(1)
+    assert ssl_context.load_cert_chain_count == 0
+    assert ssl_context.load_ca_count == 0
+
+    touch_file(key_path)
+    await asyncio.sleep(1)
+    assert ssl_context.load_cert_chain_count == 1
+    assert ssl_context.load_ca_count == 0
+
+    touch_file(cert_path)
+    touch_file(ca_path)
+    await asyncio.sleep(1)
+    assert ssl_context.load_cert_chain_count == 2
+    assert ssl_context.load_ca_count == 1
+
+    ssl_refresher.stop()
+
+    touch_file(cert_path)
+    touch_file(ca_path)
+    await asyncio.sleep(1)
+    assert ssl_context.load_cert_chain_count == 2
+    assert ssl_context.load_ca_count == 1
diff --git a/vllm/entrypoints/api_server.py b/vllm/entrypoints/api_server.py
index 00793d4b9677..9ad3c3786166 100644
--- a/vllm/entrypoints/api_server.py
+++ b/vllm/entrypoints/api_server.py
@@ -128,6 +128,7 @@ async def run_server(args: Namespace,
     shutdown_task = await serve_http(
         app,
         sock=None,
+        enable_ssl_refresh=args.enable_ssl_refresh,
         host=args.host,
         port=args.port,
         log_level=args.log_level,
@@ -152,6 +153,11 @@ async def run_server(args: Namespace,
                         type=str,
                         default=None,
                         help="The CA certificates file")
+    parser.add_argument(
+        "--enable-ssl-refresh",
+        action="store_true",
+        default=False,
+        help="Refresh SSL Context when SSL certificate files change")
     parser.add_argument(
         "--ssl-cert-reqs",
         type=int,
diff --git a/vllm/entrypoints/launcher.py b/vllm/entrypoints/launcher.py
index 79946a498dad..b09ee526f14a 100644
--- a/vllm/entrypoints/launcher.py
+++ b/vllm/entrypoints/launcher.py
@@ -12,13 +12,16 @@
 from vllm import envs
 from vllm.engine.async_llm_engine import AsyncEngineDeadError
 from vllm.engine.multiprocessing import MQEngineDeadError
+from vllm.entrypoints.ssl import SSLCertRefresher
 from vllm.logger import init_logger
 from vllm.utils import find_process_using_port
 
 logger = init_logger(__name__)
 
 
-async def serve_http(app: FastAPI, sock: Optional[socket.socket],
+async def serve_http(app: FastAPI,
+                     sock: Optional[socket.socket],
+                     enable_ssl_refresh: bool = False,
                      **uvicorn_kwargs: Any):
     logger.info("Available routes are:")
     for route in app.routes:
@@ -31,6 +34,7 @@ async def serve_http(app: FastAPI, sock: Optional[socket.socket],
         logger.info("Route: %s, Methods: %s", path, ', '.join(methods))
 
     config = uvicorn.Config(app, **uvicorn_kwargs)
+    config.load()
     server = uvicorn.Server(config)
     _add_shutdown_handlers(app, server)
 
@@ -39,9 +43,17 @@ async def serve_http(app: FastAPI, sock: Optional[socket.socket],
     server_task = loop.create_task(
         server.serve(sockets=[sock] if sock else None))
 
+    ssl_cert_refresher = None if not enable_ssl_refresh else SSLCertRefresher(
+        ssl_context=config.ssl,
+        key_path=config.ssl_keyfile,
+        cert_path=config.ssl_certfile,
+        ca_path=config.ssl_ca_certs)
+
     def signal_handler() -> None:
         # prevents the uvicorn signal handler to exit early
         server_task.cancel()
+        if ssl_cert_refresher:
+            ssl_cert_refresher.stop()
 
     async def dummy_shutdown() -> None:
         pass
diff --git a/vllm/entrypoints/openai/api_server.py b/vllm/entrypoints/openai/api_server.py
index ad391d6737bf..5376633515c9 100644
--- a/vllm/entrypoints/openai/api_server.py
+++ b/vllm/entrypoints/openai/api_server.py
@@ -940,6 +940,7 @@ def _listen_addr(a: str) -> str:
         shutdown_task = await serve_http(
             app,
             sock=sock,
+            enable_ssl_refresh=args.enable_ssl_refresh,
             host=args.host,
             port=args.port,
             log_level=args.uvicorn_log_level,
diff --git a/vllm/entrypoints/openai/cli_args.py b/vllm/entrypoints/openai/cli_args.py
index 3054958f3c8a..ba953c219708 100644
--- a/vllm/entrypoints/openai/cli_args.py
+++ b/vllm/entrypoints/openai/cli_args.py
@@ -164,6 +164,11 @@ def make_arg_parser(parser: FlexibleArgumentParser) -> FlexibleArgumentParser:
                         type=nullable_str,
                         default=None,
                         help="The CA certificates file.")
+    parser.add_argument(
+        "--enable-ssl-refresh",
+        action="store_true",
+        default=False,
+        help="Refresh SSL Context when SSL certificate files change")
     parser.add_argument(
         "--ssl-cert-reqs",
         type=int,
diff --git a/vllm/entrypoints/ssl.py b/vllm/entrypoints/ssl.py
new file mode 100644
index 000000000000..dba916b8bf13
--- /dev/null
+++ b/vllm/entrypoints/ssl.py
@@ -0,0 +1,74 @@
+# SPDX-License-Identifier: Apache-2.0
+
+import asyncio
+from ssl import SSLContext
+from typing import Callable, Optional
+
+from watchfiles import Change, awatch
+
+from vllm.logger import init_logger
+
+logger = init_logger(__name__)
+
+
+class SSLCertRefresher:
+    """A class that monitors SSL certificate files and
+    reloads them when they change.
+    """
+
+    def __init__(self,
+                 ssl_context: SSLContext,
+                 key_path: Optional[str] = None,
+                 cert_path: Optional[str] = None,
+                 ca_path: Optional[str] = None) -> None:
+        self.ssl = ssl_context
+        self.key_path = key_path
+        self.cert_path = cert_path
+        self.ca_path = ca_path
+
+        # Setup certification chain watcher
+        def update_ssl_cert_chain(change: Change, file_path: str) -> None:
+            logger.info("Reloading SSL certificate chain")
+            assert self.key_path and self.cert_path
+            self.ssl.load_cert_chain(self.cert_path, self.key_path)
+
+        self.watch_ssl_cert_task = None
+        if self.key_path and self.cert_path:
+            self.watch_ssl_cert_task = asyncio.create_task(
+                self._watch_files([self.key_path, self.cert_path],
+                                  update_ssl_cert_chain))
+
+        # Setup CA files watcher
+        def update_ssl_ca(change: Change, file_path: str) -> None:
+            logger.info("Reloading SSL CA certificates")
+            assert self.ca_path
+            self.ssl.load_verify_locations(self.ca_path)
+
+        self.watch_ssl_ca_task = None
+        if self.ca_path:
+            self.watch_ssl_ca_task = asyncio.create_task(
+                self._watch_files([self.ca_path], update_ssl_ca))
+
+    async def _watch_files(self, paths, fun: Callable[[Change, str],
+                                                      None]) -> None:
+        """Watch multiple file paths asynchronously."""
+        logger.info("SSLCertRefresher monitors files: %s", paths)
+        async for changes in awatch(*paths):
+            try:
+                for change, file_path in changes:
+                    logger.info("File change detected: %s - %s", change.name,
+                                file_path)
+                    fun(change, file_path)
+            except Exception as e:
+                logger.error(
+                    "SSLCertRefresher failed taking action on file change. "
+                    "Error: %s", e)
+
+    def stop(self) -> None:
+        """Stop watching files."""
+        if self.watch_ssl_cert_task:
+            self.watch_ssl_cert_task.cancel()
+            self.watch_ssl_cert_task = None
+        if self.watch_ssl_ca_task:
+            self.watch_ssl_ca_task.cancel()
+            self.watch_ssl_ca_task = None