diff --git a/vllm/envs.py b/vllm/envs.py
index 45547416314f..8a8ad3a88e13 100644
--- a/vllm/envs.py
+++ b/vllm/envs.py
@@ -74,6 +74,7 @@
     VLLM_SKIP_P2P_CHECK: bool = False
     VLLM_DISABLED_KERNELS: List[str] = []
     VLLM_USE_V1: bool = False
+    VLLM_ROCM_FP8_PADDING: bool = True
     VLLM_ENABLE_V1_MULTIPROCESSING: bool = True
     VLLM_LOG_BATCHSIZE_INTERVAL: float = -1
     VLLM_DISABLE_COMPILE_CACHE: bool = False
@@ -503,6 +504,9 @@ def maybe_convert_int(value: Optional[str]) -> Optional[int]:
     "VLLM_USE_V1":
     lambda: bool(int(os.getenv("VLLM_USE_V1", "0"))),
 
+    # Pad the fp8 weights to 256 bytes for ROCm
+    "VLLM_ROCM_FP8_PADDING":
+    lambda: bool(int(os.getenv("VLLM_ROCM_FP8_PADDING", "1"))),
     # Divisor for dynamic key scale factor calculation for FP8 KV Cache
     "K_SCALE_CONSTANT":
     lambda: int(os.getenv("K_SCALE_CONSTANT", "200")),
diff --git a/vllm/model_executor/layers/quantization/fp8.py b/vllm/model_executor/layers/quantization/fp8.py
index fe8ff7ca5e12..1ca39b0ffa82 100644
--- a/vllm/model_executor/layers/quantization/fp8.py
+++ b/vllm/model_executor/layers/quantization/fp8.py
@@ -3,6 +3,7 @@
 from typing import Any, Callable, Dict, List, Optional
 
 import torch
+import torch.nn.functional as F
 from torch.nn import Module
 from torch.nn.parameter import Parameter
 
@@ -251,6 +252,17 @@ def create_weights(
             else:
                 layer.register_parameter("input_scale", None)
 
+    def add_padding_to_weight(self, weight: torch.Tensor) -> torch.Tensor:
+        # Pad the weight tensor. This is an optimization on ROCm platform, which
+        # can benefit from tensors located far enough from one another in memory
+        if (envs.VLLM_ROCM_FP8_PADDING and current_platform.is_rocm()
+                and weight.stride(-1) == 1
+                and (weight.stride(-2) * weight.element_size()) % 512 == 0):
+            num_pad = 256 // weight.element_size()
+            weight = F.pad(weight, (0, num_pad), "constant", 0)[..., :-num_pad]
+            torch.cuda.empty_cache()
+        return weight
+
     def process_weights_after_loading(self, layer: Module) -> None:
         # TODO(rob): refactor block quant into separate class.
         if self.block_quant:
@@ -264,6 +276,8 @@ def process_weights_after_loading(self, layer: Module) -> None:
                 weight = layer.weight.data
                 weight_scale_inv = layer.weight_scale_inv.data
 
+            weight = self.add_padding_to_weight(weight)
+
             # Torch.compile cannot use Parameter subclasses.
             layer.weight = Parameter(weight, requires_grad=False)
             layer.weight_scale_inv = Parameter(weight_scale_inv,
@@ -327,6 +341,7 @@ def process_weights_after_loading(self, layer: Module) -> None:
                     logical_widths=layer.logical_widths,
                 )
 
+            weight = self.add_padding_to_weight(weight)
             # Update layer with new values.
             layer.weight = Parameter(weight.t(), requires_grad=False)
             layer.weight_scale = Parameter(weight_scale, requires_grad=False)
diff --git a/vllm/model_executor/layers/quantization/utils/fp8_utils.py b/vllm/model_executor/layers/quantization/utils/fp8_utils.py
index 9895537c219a..cd584b62eefb 100644
--- a/vllm/model_executor/layers/quantization/utils/fp8_utils.py
+++ b/vllm/model_executor/layers/quantization/utils/fp8_utils.py
@@ -477,7 +477,7 @@ def w8a8_block_fp8_matmul(
     assert triton.cdiv(A.shape[-1], block_k) == As.shape[-1]
     M = A.numel() // A.shape[-1]
 
-    assert B.ndim == 2 and B.is_contiguous() and Bs.ndim == 2
+    assert B.ndim == 2 and Bs.ndim == 2
     N, K = B.shape
     assert triton.cdiv(N, block_n) == Bs.shape[0]
     assert triton.cdiv(K, block_k) == Bs.shape[1]