diff --git a/vllm_spyre_next/pyproject.toml b/vllm_spyre_next/pyproject.toml
index 7eb841297..9be45883e 100644
--- a/vllm_spyre_next/pyproject.toml
+++ b/vllm_spyre_next/pyproject.toml
@@ -11,7 +11,7 @@ description = "Next iteration of vllm-spyre on the torch-spyre stack"
 readme = "README.md"
 license = {text = "Apache 2"}
 dependencies = [
-    "torch-spyre",
+    "torch-spyre ; sys_platform != 'darwin'",
     "vllm==0.15.1+cpu",
 
     # Listing as direct deps to ensure they're picked up from the correct index.
@@ -228,11 +228,11 @@ upstream-tests = [
     "albumentations>=1.4.6",
     "arctic-inference==0.1.1",
     "backoff>=2.2.1",
-    "bitsandbytes==0.46.1",
+    "bitsandbytes==0.46.1 ; sys_platform != 'darwin'",
     "blobfile>=3.2.0",
     "buildkite-test-collector==0.1.9",
     "datamodel-code-generator>=0.54.1",
-    "decord==0.6.0",
+    "decord==0.6.0 ; sys_platform != 'darwin'",
     "einops>=0.8.2",
     "fastsafetensors>=0.2.2",
     "genai-perf>=0.0.8",
@@ -262,7 +262,7 @@ upstream-tests = [
     "pytest-shard>=0.1.2",
     "pytest-timeout>=2.3.1",
     "ray[cgraph,default]>=2.48.0",
-    "runai-model-streamer[gcs,s3]==0.15.3",
+    "runai-model-streamer[gcs,s3]==0.15.3 ; sys_platform != 'darwin'",
     "schemathesis>=3.39.15",
     "sentence-transformers>=5.2.0",
     "soundfile>=0.13.1",
diff --git a/vllm_spyre_next/uv.lock b/vllm_spyre_next/uv.lock
index e54a953c6..4b6df261f 100644
--- a/vllm_spyre_next/uv.lock
+++ b/vllm_spyre_next/uv.lock
@@ -467,8 +467,7 @@ name = "bitsandbytes"
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+    { name = "numpy", marker = "platform_machine == 'aarch64' or sys_platform != 'darwin'" },
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-    { name = "googleapis-common-protos" },
-    { name = "proto-plus" },
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+    { name = "google-auth", marker = "platform_machine == 'aarch64' or sys_platform != 'darwin'" },
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 version = "2.5.0"
 source = { registry = "https://pypi.org/simple" }
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+    { name = "google-resumable-media", marker = "platform_machine == 'aarch64' or sys_platform != 'darwin'" },
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     { name = "torch", version = "2.10.0+cpu", source = { registry = "https://download.pytorch.org/whl/cpu" }, marker = "(platform_machine == 'aarch64' and platform_machine not in 's390x, ppc64le') or (platform_machine not in 's390x, ppc64le' and sys_platform != 'darwin')" },
-    { name = "torch-spyre" },
+    { name = "torch-spyre", marker = "sys_platform != 'darwin'" },
     { name = "torchvision", version = "0.25.0", source = { registry = "https://download.pytorch.org/whl/cpu" }, marker = "platform_machine != 'aarch64' and sys_platform == 'darwin'" },
     { name = "torchvision", version = "0.25.0+cpu", source = { registry = "https://download.pytorch.org/whl/cpu" }, marker = "platform_machine == 'aarch64' or sys_platform != 'darwin'" },
     { name = "vllm", marker = "platform_machine not in 's390x, ppc64le'" },
@@ -9225,11 +9219,11 @@ upstream-tests = [
     { name = "albumentations" },
     { name = "arctic-inference", marker = "sys_platform == 'never'" },
     { name = "backoff" },
-    { name = "bitsandbytes" },
+    { name = "bitsandbytes", marker = "sys_platform != 'darwin'" },
     { name = "blobfile" },
     { name = "buildkite-test-collector" },
     { name = "datamodel-code-generator" },
-    { name = "decord" },
+    { name = "decord", marker = "sys_platform != 'darwin'" },
     { name = "einops" },
     { name = "fastsafetensors" },
     { name = "genai-perf" },
@@ -9259,7 +9253,7 @@ upstream-tests = [
     { name = "pytest-shard" },
     { name = "pytest-timeout" },
     { name = "ray", marker = "platform_machine not in 's390x, ppc64le'" },
-    { name = "runai-model-streamer", extra = ["gcs", "s3"] },
+    { name = "runai-model-streamer", extra = ["gcs", "s3"], marker = "sys_platform != 'darwin'" },
     { name = "schemathesis" },
     { name = "sentence-transformers" },
     { name = "soundfile" },
@@ -9283,7 +9277,7 @@ upstream-tests = [
 [package.metadata]
 requires-dist = [
     { name = "torch", index = "https://download.pytorch.org/whl/cpu" },
-    { name = "torch-spyre", git = "https://github.com/torch-spyre/torch-spyre?rev=bd7502baa9123d292e56dbd4928147969ecdf63c" },
+    { name = "torch-spyre", marker = "sys_platform != 'darwin'", git = "https://github.com/torch-spyre/torch-spyre?rev=bd7502baa9123d292e56dbd4928147969ecdf63c" },
     { name = "torchvision", index = "https://download.pytorch.org/whl/cpu" },
     { name = "vllm", git = "https://github.com/vllm-project/vllm?rev=2d5be1dd5ce2e44dfea53ea03ff61143da5137eb" },
 ]
@@ -9294,11 +9288,11 @@ upstream-tests = [
     { name = "albumentations", specifier = ">=1.4.6" },
     { name = "arctic-inference", specifier = "==0.1.1" },
     { name = "backoff", specifier = ">=2.2.1" },
-    { name = "bitsandbytes", specifier = "==0.46.1" },
+    { name = "bitsandbytes", marker = "sys_platform != 'darwin'", specifier = "==0.46.1" },
     { name = "blobfile", specifier = ">=3.2.0" },
     { name = "buildkite-test-collector", specifier = "==0.1.9" },
     { name = "datamodel-code-generator", specifier = ">=0.54.1" },
-    { name = "decord", specifier = "==0.6.0" },
+    { name = "decord", marker = "sys_platform != 'darwin'", specifier = "==0.6.0" },
     { name = "einops", specifier = ">=0.8.2" },
     { name = "fastsafetensors", specifier = ">=0.2.2" },
     { name = "genai-perf", specifier = ">=0.0.8" },
@@ -9328,7 +9322,7 @@ upstream-tests = [
     { name = "pytest-shard", specifier = ">=0.1.2" },
     { name = "pytest-timeout", specifier = ">=2.3.1" },
     { name = "ray", extras = ["cgraph", "default"], specifier = ">=2.48.0" },
-    { name = "runai-model-streamer", extras = ["gcs", "s3"], specifier = "==0.15.3" },
+    { name = "runai-model-streamer", extras = ["gcs", "s3"], marker = "sys_platform != 'darwin'", specifier = "==0.15.3" },
     { name = "schemathesis", specifier = ">=3.39.15" },
     { name = "sentence-transformers", specifier = ">=5.2.0" },
     { name = "soundfile", specifier = ">=0.13.1" },