diff --git a/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml b/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
index c225a5b880c..0ca011f2564 100644
--- a/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
+++ b/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
@@ -243,6 +243,12 @@ crm/test_crm.py::test_crm_fdb_entry:
     conditions:
       - "'t0' not in topo_name and topo_type not in ['m0', 'mx']"
 
+crm/test_crm.py::test_crm_route:
+  skip:
+    reason: "Skip the test on mellanox  device due to the bug of https://github.com/sonic-net/sonic-mgmt/issues/12725"
+    conditions:
+      - https://github.com/sonic-net/sonic-mgmt/issues/12725
+      - "asic_type in ['mellanox']"
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