diff --git a/packages/react-core/src/components/FileUpload/FileUpload.tsx b/packages/react-core/src/components/FileUpload/FileUpload.tsx
index df2b34a5816..032bea86611 100644
--- a/packages/react-core/src/components/FileUpload/FileUpload.tsx
+++ b/packages/react-core/src/components/FileUpload/FileUpload.tsx
@@ -47,17 +47,6 @@ export interface FileUploadProps
   isReadOnly?: boolean;
   /** Flag to show if the field is required. */
   isRequired?: boolean;
-  /** @deprecated A callback for when the file contents changes. Please instead use
-   * onFileInputChange, onTextChange, onDataChange, and onClearClick individually.
-   */
-  onChange?: (
-    value: string | File,
-    filename: string,
-    event:
-      | React.MouseEvent<HTMLButtonElement, MouseEvent> // Clear button was clicked
-      | React.DragEvent<HTMLElement> // User dragged/dropped a file
-      | React.ChangeEvent<HTMLElement> // User typed in the TextArea
-  ) => void;
   /** Callback for clicking on the file upload field text area. By default, prevents a click
    * in the text area from opening file dialog.
    */
@@ -66,7 +55,7 @@ export interface FileUploadProps
   onFileInputChange?: (event: React.ChangeEvent<HTMLInputElement> | React.DragEvent<HTMLElement>, file: File) => void;
   /** Aria-valuetext for the loading spinner. */
   spinnerAriaValueText?: string;
-  /** What type of file. Determines what is passed to the onChange property and what is
+  /** What type of file. Determines whether 'onDataChange` is called and what is
    * expected by the value property (a string for 'text' and 'dataURL', or a File object otherwise.
    */
   type?: 'text' | 'dataURL';
@@ -102,7 +91,6 @@ export const FileUpload: React.FunctionComponent<FileUploadProps> = ({
   value = type === fileReaderType.text || type === fileReaderType.dataURL ? '' : null,
   filename = '',
   children = null,
-  onChange = () => {},
   onFileInputChange = null,
   onReadStarted = () => {},
   onReadFinished = () => {},
@@ -121,31 +109,23 @@ export const FileUpload: React.FunctionComponent<FileUploadProps> = ({
         onFileInputChange?.(event, fileHandle);
       }
       if (type === fileReaderType.text || type === fileReaderType.dataURL) {
-        onChange('', fileHandle.name, event); // Show the filename while reading
         onReadStarted(fileHandle);
         readFile(fileHandle, type as fileReaderType)
           .then(data => {
             onReadFinished(fileHandle);
-            onChange(data as string, fileHandle.name, event);
             onDataChange?.(data as string);
           })
           .catch((error: DOMException) => {
             onReadFailed(error, fileHandle);
             onReadFinished(fileHandle);
-            onChange('', '', event); // Clear the filename field on a failure
             onDataChange?.('');
           });
-      } else {
-        onChange(fileHandle, fileHandle.name, event);
       }
     }
     dropzoneProps.onDropAccepted && dropzoneProps.onDropAccepted(acceptedFiles, event);
   };
 
   const onDropRejected: DropFileEventHandler = (rejectedFiles, event) => {
-    if (rejectedFiles.length > 0) {
-      onChange('', rejectedFiles[0].name, event);
-    }
     dropzoneProps.onDropRejected && dropzoneProps.onDropRejected(rejectedFiles, event);
   };
 
@@ -155,7 +135,6 @@ export const FileUpload: React.FunctionComponent<FileUploadProps> = ({
   };
 
   const onClearButtonClick = (event: React.MouseEvent<HTMLButtonElement, MouseEvent>) => {
-    onChange('', '', event);
     onClearClick?.(event);
     setFileValue(null);
   };
@@ -187,7 +166,6 @@ export const FileUpload: React.FunctionComponent<FileUploadProps> = ({
             type={type}
             filename={filename}
             value={value}
-            onChange={onChange}
             isDragActive={isDragActive}
             onBrowseButtonClick={open}
             onClearButtonClick={onClearButtonClick}
diff --git a/packages/react-core/src/components/FileUpload/FileUploadField.tsx b/packages/react-core/src/components/FileUpload/FileUploadField.tsx
index 808dde920a6..fa5897e37db 100644
--- a/packages/react-core/src/components/FileUpload/FileUploadField.tsx
+++ b/packages/react-core/src/components/FileUpload/FileUploadField.tsx
@@ -12,7 +12,7 @@ import { fileReaderType } from '../../helpers/fileUtils';
  * functionality is not built in by default.
  */
 
-export interface FileUploadFieldProps extends Omit<React.HTMLProps<HTMLDivElement>, 'value' | 'onChange'> {
+export interface FileUploadFieldProps extends Omit<React.HTMLProps<HTMLDivElement>, 'value'> {
   /** Flag to allow editing of a text file's contents after it is selected from disk. */
   allowEditingUploadedText?: boolean;
   /** Aria-label for the text area. */
@@ -47,14 +47,6 @@ export interface FileUploadFieldProps extends Omit<React.HTMLProps<HTMLDivElemen
   isReadOnly?: boolean;
   /** Flag to show if the field is required. */
   isRequired?: boolean;
-  /** A callback for when the text area value changes. */
-  onChange?: (
-    value: string,
-    filename: string,
-    event:
-      | React.ChangeEvent<HTMLTextAreaElement> // User typed in the TextArea
-      | React.MouseEvent<HTMLButtonElement, MouseEvent> // User clicked Clear button
-  ) => void;
   /** Aria-valuetext for the loading spinner. */
   spinnerAriaValueText?: string;
   /** What type of file. Determines what is is expected by the value property (a string for
@@ -95,7 +87,6 @@ export const FileUploadField: React.FunctionComponent<FileUploadFieldProps> = ({
   type,
   value = '',
   filename = '',
-  onChange = () => {},
   onBrowseButtonClick = () => {},
   onClearButtonClick = () => {},
   onTextAreaClick,
@@ -123,8 +114,7 @@ export const FileUploadField: React.FunctionComponent<FileUploadFieldProps> = ({
 
   ...props
 }: FileUploadFieldProps) => {
-  const onTextAreaChange = (newValue: string, event: React.ChangeEvent<HTMLTextAreaElement>) => {
-    onChange(newValue, filename, event);
+  const onTextAreaChange = (newValue: string) => {
     onTextChange?.(newValue);
   };
   return (
diff --git a/packages/react-core/src/components/FileUpload/__tests__/FileUpload.test.tsx b/packages/react-core/src/components/FileUpload/__tests__/FileUpload.test.tsx
index 077e001ef15..369ab6c089b 100644
--- a/packages/react-core/src/components/FileUpload/__tests__/FileUpload.test.tsx
+++ b/packages/react-core/src/components/FileUpload/__tests__/FileUpload.test.tsx
@@ -3,7 +3,6 @@ import * as React from 'react';
 import { render } from '@testing-library/react';
 
 test('simple fileupload', () => {
-  const changeHandler = jest.fn();
   const readStartedHandler = jest.fn();
   const readFinishedHandler = jest.fn();
 
@@ -13,7 +12,6 @@ test('simple fileupload', () => {
       type="text"
       value={''}
       filename={''}
-      onChange={changeHandler}
       onReadStarted={readStartedHandler}
       onReadFinished={readFinishedHandler}
       isLoading={false}
diff --git a/packages/react-core/src/components/FileUpload/__tests__/FileUploadField.test.tsx b/packages/react-core/src/components/FileUpload/__tests__/FileUploadField.test.tsx
index 650da01bd8e..925394a559e 100644
--- a/packages/react-core/src/components/FileUpload/__tests__/FileUploadField.test.tsx
+++ b/packages/react-core/src/components/FileUpload/__tests__/FileUploadField.test.tsx
@@ -3,7 +3,6 @@ import * as React from 'react';
 import { render } from '@testing-library/react';
 
 test('simple fileuploadfield', () => {
-  const changeHandler = jest.fn();
   const browserBtnClickHandler = jest.fn();
   const clearBtnClickHandler = jest.fn();
 
@@ -13,7 +12,6 @@ test('simple fileuploadfield', () => {
       type="text"
       value={''}
       filename={''}
-      onChange={changeHandler}
       filenamePlaceholder="Do something custom with this!"
       onBrowseButtonClick={browserBtnClickHandler}
       onClearButtonClick={clearBtnClickHandler}