diff --git a/common/djangoapps/util/course.py b/common/djangoapps/util/course.py
index abef18a3263d..f438894f75de 100644
--- a/common/djangoapps/util/course.py
+++ b/common/djangoapps/util/course.py
@@ -53,7 +53,10 @@ def get_link_for_about_page(course):
     ).get('CUSTOM_COURSE_URLS')
 
     if use_catalog_mfe():
-        about_base_url = settings.CATALOG_MICROFRONTEND_URL
+        about_base_url = configuration_helpers.get_value(
+            'CATALOG_MICROFRONTEND_URL',
+            settings.CATALOG_MICROFRONTEND_URL,
+        )
     else:
         about_base_url = configuration_helpers.get_value('LMS_ROOT_URL', settings.LMS_ROOT_URL)
 
diff --git a/lms/djangoapps/branding/views.py b/lms/djangoapps/branding/views.py
index 33c5813f16ff..b98b652ce5d7 100644
--- a/lms/djangoapps/branding/views.py
+++ b/lms/djangoapps/branding/views.py
@@ -28,6 +28,19 @@
 log = logging.getLogger(__name__)
 
 
+def _catalog_mfe_base_url() -> str:
+    """
+    Return the site-aware base URL for the Catalog MFE.
+
+    Reads `CATALOG_MICROFRONTEND_URL` from Site Configuration when available;
+    otherwise falls back to `settings.CATALOG_MICROFRONTEND_URL`.
+    """
+    return configuration_helpers.get_value(
+        'CATALOG_MICROFRONTEND_URL',
+        settings.CATALOG_MICROFRONTEND_URL,
+    )
+
+
 @ensure_csrf_cookie
 @transaction.non_atomic_requests
 @cache_if_anonymous()
@@ -46,7 +59,10 @@ def index(request):
             return redirect('dashboard')
 
     if use_catalog_mfe():
-        return redirect(f'{settings.CATALOG_MICROFRONTEND_URL}/', permanent=True)
+        return redirect(
+            f'{_catalog_mfe_base_url()}/',
+            permanent=True,
+        )
 
     enable_mktg_site = configuration_helpers.get_value(
         'ENABLE_MKTG_SITE',
@@ -94,7 +110,10 @@ def courses(request):
     profile page. Otherwise, it's the edX courseware.views.views.courses page
     """
     if use_catalog_mfe():
-        return redirect(f'{settings.CATALOG_MICROFRONTEND_URL}/courses', permanent=True)
+        return redirect(
+            f'{_catalog_mfe_base_url()}/',
+            permanent=True,
+        )
 
     enable_mktg_site = configuration_helpers.get_value(
         'ENABLE_MKTG_SITE',
diff --git a/lms/djangoapps/learner_home/serializers.py b/lms/djangoapps/learner_home/serializers.py
index f7eed25d22e9..daac3a29ecc3 100644
--- a/lms/djangoapps/learner_home/serializers.py
+++ b/lms/djangoapps/learner_home/serializers.py
@@ -14,6 +14,7 @@
 
 from common.djangoapps.course_modes.models import CourseMode
 from openedx.features.course_experience import course_home_url
+from openedx.core.djangoapps.site_configuration import helpers as configuration_helpers
 from xmodule.data import CertificatesDisplayBehaviors
 from lms.djangoapps.learner_home.utils import course_progress_url
 
@@ -595,8 +596,10 @@ class EnterpriseDashboardSerializer(serializers.Serializer):
 
     def get_url(self, instance):
         return urljoin(
-            settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
-            instance["slug"],
+            configuration_helpers.get_value(
+                'ENTERPRISE_LEARNER_PORTAL_BASE_URL',
+                settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+            ),
         )
 
 
diff --git a/lms/djangoapps/learner_home/views.py b/lms/djangoapps/learner_home/views.py
index 40962721b339..9b3a2984c7dd 100644
--- a/lms/djangoapps/learner_home/views.py
+++ b/lms/djangoapps/learner_home/views.py
@@ -73,8 +73,12 @@ def get_platform_settings():
     """Get settings used for platform level connections: emails, url routes, etc."""
 
     course_search_url = marketing_link("COURSES")
+    catalog_microfrontend_url = configuration_helpers.get_value(
+        "CATALOG_MICROFRONTEND_URL",
+        settings.CATALOG_MICROFRONTEND_URL,
+    )
     if toggles.use_catalog_mfe():
-        course_search_url = f"{settings.CATALOG_MICROFRONTEND_URL}/courses"
+        course_search_url = f"{catalog_microfrontend_url}/courses"
 
     return {
         "supportEmail": settings.DEFAULT_FEEDBACK_EMAIL,
diff --git a/lms/djangoapps/program_enrollments/management/commands/send_program_course_nudge_email.py b/lms/djangoapps/program_enrollments/management/commands/send_program_course_nudge_email.py
index af2bfdca752d..80c63a6f32bc 100644
--- a/lms/djangoapps/program_enrollments/management/commands/send_program_course_nudge_email.py
+++ b/lms/djangoapps/program_enrollments/management/commands/send_program_course_nudge_email.py
@@ -23,6 +23,7 @@
 from openedx.core.constants import COURSE_PUBLISHED
 from openedx.core.djangoapps.catalog.utils import get_programs
 from openedx.core.djangoapps.programs.utils import ProgramProgressMeter
+from openedx.core.djangoapps.site_configuration import helpers as configuration_helpers
 from openedx.features.enterprise_support.api import get_enterprise_learner_data_from_db
 
 User = get_user_model()
@@ -190,7 +191,10 @@ def emit_event(self, user, program, suggested_course_run, suggested_course, comp
         if enterprise_customer and enterprise_customer['enable_learner_portal']:
             # If user is an enterprise learner then we want to redirect to B2B course landing page on learner portal.
             recommended_course_url = urljoin(
-                settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+                configuration_helpers.get_value(
+                    'ENTERPRISE_LEARNER_PORTAL_BASE_URL',
+                    settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+                ),
                 '/'.join([enterprise_customer['slug'], 'course', suggested_course['key']]),
             )
         else:
diff --git a/lms/templates/header/navbar-logo-header.html b/lms/templates/header/navbar-logo-header.html
index adb12deec16f..9c0ae62b23a0 100644
--- a/lms/templates/header/navbar-logo-header.html
+++ b/lms/templates/header/navbar-logo-header.html
@@ -20,7 +20,7 @@
 
 <h1 class="header-logo">
   % if enterprise_customer_link:
-    <a href="${settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL}/${enterprise_customer_link.get('slug')}">
+    <a href="${configuration_helpers.get_value('ENTERPRISE_LEARNER_PORTAL_BASE_URL', settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL)}/${enterprise_customer_link.get('slug')}">
       <img class="logo" src="${enterprise_customer_link.get('logo')}" alt="${_('{name} Dashboard').format(name=enterprise_customer_link.get('name'))}"/>
         % if settings.LOGO_IMAGE_EXTRA_TEXT == 'edge':
             <span class="font-italic"> | EDGE</span>
diff --git a/lms/templates/header/user_dropdown.html b/lms/templates/header/user_dropdown.html
index a489c17412b9..eb4c4a26a4ae 100644
--- a/lms/templates/header/user_dropdown.html
+++ b/lms/templates/header/user_dropdown.html
@@ -11,6 +11,7 @@
 from django.utils.translation import gettext as _
 
 from openedx.core.djangoapps.user_api.accounts.image_helpers import get_profile_image_urls_for_user
+from openedx.core.djangoapps.site_configuration import helpers as configuration_helpers
 from openedx.features.enterprise_support.utils import get_enterprise_learner_generic_name, get_enterprise_learner_portal
 %>
 
@@ -41,13 +42,13 @@
         % if not enterprise_customer_portal:
             <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${reverse('dashboard')}" role="menuitem">${_("Dashboard")}</a></div>
         % else:
-            <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL}/${enterprise_customer_portal.get('slug')}" role="menuitem">${_("Dashboard")}</a></div>
+            <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${configuration_helpers.get_value('ENTERPRISE_LEARNER_PORTAL_BASE_URL', settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL)}/${enterprise_customer_portal.get('slug')}" role="menuitem">${_("Dashboard")}</a></div>
         % endif
 
         <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${urljoin(settings.PROFILE_MICROFRONTEND_URL, f'{user.username}')}" role="menuitem">${_("Profile")}</a></div>
         <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${settings.ACCOUNT_MICROFRONTEND_URL}" role="menuitem">${_("Account")}</a></div>
         % if should_show_order_history:
-            <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${settings.ORDER_HISTORY_MICROFRONTEND_URL}" role="menuitem">${_("Order History")}</a></div>
+            <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${configuration_helpers.get_value('ORDER_HISTORY_MICROFRONTEND_URL', settings.ORDER_HISTORY_MICROFRONTEND_URL)}" role="menuitem">${_("Order History")}</a></div>
         % endif
         <div class="mobile-nav-item dropdown-item dropdown-nav-item"><a href="${reverse('logout')}" role="menuitem">${_("Sign Out")}</a></div>
     </div>
diff --git a/openedx/features/enterprise_support/api.py b/openedx/features/enterprise_support/api.py
index 32c493d1e35e..0b1846cdaf1a 100644
--- a/openedx/features/enterprise_support/api.py
+++ b/openedx/features/enterprise_support/api.py
@@ -895,7 +895,10 @@ def get_enterprise_learner_portal_enabled_message(enterprise_customer):
         return None
 
     learner_portal_url = "{base_url}/{slug}?utm_source=lms_dashboard_banner".format(
-        base_url=settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+        base_url=configuration_helpers.get_value(
+            'ENTERPRISE_LEARNER_PORTAL_BASE_URL',
+            settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+        ),
         slug=enterprise_customer['slug']
     )
 
@@ -935,7 +938,10 @@ def get_enterprise_learner_portal_context(request):
         'enterprise_customer_slug': enterprise_customer.get('slug'),
         'enterprise_customer_learner_portal_enabled': enterprise_customer.get('enable_learner_portal', False),
         'enterprise_customer_uuid': enterprise_customer.get('uuid'),
-        'enterprise_learner_portal_base_url': settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+        'enterprise_learner_portal_base_url': configuration_helpers.get_value(
+            'ENTERPRISE_LEARNER_PORTAL_BASE_URL',
+            settings.ENTERPRISE_LEARNER_PORTAL_BASE_URL,
+        ),
         'enterprise_learner_portal_enabled_message': enterprise_learner_portal_enabled_message,
     })
     return context