diff --git a/common.gypi b/common.gypi
index 73dfecc46b879e..55476f5ce2b184 100644
--- a/common.gypi
+++ b/common.gypi
@@ -449,9 +449,6 @@
       ['v8_enable_pointer_compression_shared_cage == 1', {
         'defines': ['V8_COMPRESS_POINTERS_IN_SHARED_CAGE'],
       }],
-      ['v8_enable_pointer_compression == 1 and v8_enable_pointer_compression_shared_cage != 1', {
-        'defines': ['V8_COMPRESS_POINTERS_IN_ISOLATE_CAGE'],
-      }],
       ['v8_enable_pointer_compression == 1 or v8_enable_31bit_smis_on_64bit_arch == 1', {
         'defines': ['V8_31BIT_SMIS_ON_64BIT_ARCH'],
       }],
diff --git a/tools/v8_gypfiles/features.gypi b/tools/v8_gypfiles/features.gypi
index 263ac8213f0aa2..e62b69e9a7175f 100644
--- a/tools/v8_gypfiles/features.gypi
+++ b/tools/v8_gypfiles/features.gypi
@@ -361,9 +361,6 @@
       ['v8_enable_pointer_compression_shared_cage==1', {
         'defines': ['V8_COMPRESS_POINTERS_IN_SHARED_CAGE'],
       }],
-      ['v8_enable_pointer_compression==1 and v8_enable_pointer_compression_shared_cage==0', {
-        'defines': ['V8_COMPRESS_POINTERS_IN_ISOLATE_CAGE'],
-      }],
       ['v8_enable_pointer_compression==1 or v8_enable_31bit_smis_on_64bit_arch==1', {
         'defines': ['V8_31BIT_SMIS_ON_64BIT_ARCH',],
       }],