diff --git a/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.test.tsx b/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.test.tsx
index 063dba26ff..c262c50f5c 100644
--- a/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.test.tsx
+++ b/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.test.tsx
@@ -1,3 +1,4 @@
+import { act } from '@testing-library/react';
 import { createContextContainer, render, screen, tests, userEvent } from '@mantine-tests/core';
 import { Menu } from '../Menu';
 import { MenuItem, MenuItemProps, MenuItemStylesNames } from './MenuItem';
@@ -57,4 +58,124 @@ describe('@mantine/core/MenuItem', () => {
     expect(screen.getByText('test-left-section')).toBeInTheDocument();
     expect(screen.getByText('test-right-section')).toBeInTheDocument();
   });
+
+  it('should not prevent default mousedown behavior for draggable elements inside Menu.Item', () => {
+    const onDragStart = jest.fn();
+    const onMouseDown = jest.fn();
+
+    render(
+      <Menu opened closeOnItemClick={false} withInitialFocusPlaceholder={false}>
+        <Menu.Target>
+          <button type="button">Target</button>
+        </Menu.Target>
+        <Menu.Dropdown>
+          <Menu.Item>
+            <div
+              data-testid="draggable-element"
+              draggable
+              onDragStart={onDragStart}
+              onMouseDown={onMouseDown}
+              role="button"
+              tabIndex={0}
+            >
+              Draggable content
+            </div>
+          </Menu.Item>
+        </Menu.Dropdown>
+      </Menu>
+    );
+
+    const draggableElement = screen.getByTestId('draggable-element');
+
+    const mouseDownEvent = new MouseEvent('mousedown', {
+      bubbles: true,
+      cancelable: true,
+      button: 0, // left mouse button
+    });
+
+    const preventDefaultSpy = jest.spyOn(mouseDownEvent, 'preventDefault');
+
+    act(() => {
+      draggableElement.dispatchEvent(mouseDownEvent);
+    });
+
+    expect(onMouseDown).toHaveBeenCalled();
+
+    expect(preventDefaultSpy).not.toHaveBeenCalled();
+  });
+
+  it('should still prevent default mousedown behavior for non-draggable elements', () => {
+    const onMouseDown = jest.fn();
+
+    render(
+      <Menu opened closeOnItemClick={false} withInitialFocusPlaceholder={false}>
+        <Menu.Target>
+          <button type="button">Target</button>
+        </Menu.Target>
+        <Menu.Dropdown>
+          <Menu.Item>
+            <div data-testid="regular-element" onMouseDown={onMouseDown} role="button" tabIndex={0}>
+              Regular content
+            </div>
+          </Menu.Item>
+        </Menu.Dropdown>
+      </Menu>
+    );
+
+    const regularElement = screen.getByTestId('regular-element');
+
+    const mouseDownEvent = new MouseEvent('mousedown', {
+      bubbles: true,
+      cancelable: true,
+      button: 0,
+    });
+
+    const preventDefaultSpy = jest.spyOn(mouseDownEvent, 'preventDefault');
+
+    act(() => {
+      regularElement.dispatchEvent(mouseDownEvent);
+    });
+
+    expect(onMouseDown).toHaveBeenCalled();
+
+    expect(preventDefaultSpy).toHaveBeenCalled();
+  });
+
+  it('should not prevent default mousedown for interactive elements', () => {
+    const onMouseDown = jest.fn();
+
+    render(
+      <Menu opened closeOnItemClick={false} withInitialFocusPlaceholder={false}>
+        <Menu.Target>
+          <button type="button">Target</button>
+        </Menu.Target>
+        <Menu.Dropdown>
+          <Menu.Item>
+            <input
+              data-testid="input-element"
+              type="text"
+              onMouseDown={onMouseDown}
+              placeholder="Test input"
+            />
+          </Menu.Item>
+        </Menu.Dropdown>
+      </Menu>
+    );
+
+    const inputElement = screen.getByTestId('input-element');
+    const mouseDownEvent = new MouseEvent('mousedown', {
+      bubbles: true,
+      cancelable: true,
+      button: 0,
+    });
+
+    const preventDefaultSpy = jest.spyOn(mouseDownEvent, 'preventDefault');
+
+    act(() => {
+      inputElement.dispatchEvent(mouseDownEvent);
+    });
+
+    expect(onMouseDown).toHaveBeenCalled();
+    expect(preventDefaultSpy).not.toHaveBeenCalled();
+  });
 });
diff --git a/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.tsx b/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.tsx
index 4f8ea1f41c..00e96f14f0 100644
--- a/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.tsx
+++ b/packages/@mantine/core/src/components/Menu/MenuItem/MenuItem.tsx
@@ -97,9 +97,26 @@ export const MenuItem = polymorphicFactory<MenuItemFactory>((props, ref) => {
     }
   });
 
+  const handleMouseDown = createEventHandler<any>(_others.onMouseDown, (event) => {
+    let target = event.target as Element;
+    while (target && target !== event.currentTarget) {
+      if (target.getAttribute) {
+        if (
+          target.getAttribute('draggable') === 'true' ||
+          ['INPUT', 'TEXTAREA', 'SELECT', 'BUTTON', 'A'].includes(target.tagName) ||
+          target.getAttribute('contenteditable') === 'true'
+        ) {
+          return;
+        }
+      }
+      target = target.parentElement as Element;
+    }
+    event.preventDefault();
+  });
+
   return (
     <UnstyledButton
-      onMouseDown={(event) => event.preventDefault()}
+      onMouseDown={handleMouseDown}
       {...others}
       unstyled={ctx.unstyled}
       tabIndex={ctx.menuItemTabIndex}