diff --git a/.github/actions/1-setup/action.yml b/.github/actions/1-setup/action.yml
index 68ece5b0ee3..48726d0ae99 100644
--- a/.github/actions/1-setup/action.yml
+++ b/.github/actions/1-setup/action.yml
@@ -37,16 +37,6 @@ runs:
         # Make sure to link libzstd statically
         sudo rm /usr/lib/$arch-linux-gnu/libzstd.so
 
-        # Install a more recent CMake version in the AArch64 container (for mimalloc...)
-        if [[ $arch == aarch64 ]]; then
-          curl -fL --retry 3 --max-time 300 -o cmake.tar.gz \
-            https://github.com/Kitware/CMake/releases/download/v3.31.4/cmake-3.31.4-linux-$arch.tar.gz
-          mkdir cmake
-          tar -xf cmake.tar.gz --strip 1 -C cmake
-          rm cmake.tar.gz
-          sudo ln -sf $PWD/cmake/bin/cmake /usr/bin/cmake
-        fi
-
     - name: 'Linux: Install clang 19 from apt.llvm.org'
       if: runner.os == 'Linux'
       shell: bash
diff --git a/.github/actions/4b-test-lit/action.yml b/.github/actions/4b-test-lit/action.yml
index 0c7bfd106e9..7d4c58c7544 100644
--- a/.github/actions/4b-test-lit/action.yml
+++ b/.github/actions/4b-test-lit/action.yml
@@ -15,7 +15,6 @@ runs:
         if [[ '${{ runner.os }}-${{ inputs.arch }}' == Linux-aarch64 ]]; then
           # FIXME: the following tests fail
           rm tests/debuginfo/nested_gdb.d
-          rm tests/debuginfo/print_gdb.d # works for Cirrus CI though
           rm tests/sanitizers/fuzz_basic.d
         fi
 
diff --git a/.github/actions/4d-test-libs/action.yml b/.github/actions/4d-test-libs/action.yml
index fb83069b140..52257977a9d 100644
--- a/.github/actions/4d-test-libs/action.yml
+++ b/.github/actions/4d-test-libs/action.yml
@@ -19,7 +19,10 @@ runs:
         fi
 
         excludes="dmd-testsuite|lit-tests|ldc2-unittest"
-        if [[ '${{ runner.os }}-${{ inputs.arch }}' == Linux-aarch64 ]]; then
+        if [[ '${{ runner.os }}-${{ inputs.arch }}' == Linux-x86_64 ]]; then
+          # sporadically hanging since Ubuntu 22
+          excludes+='|^core.thread-shared_32$'
+        elif [[ '${{ runner.os }}-${{ inputs.arch }}' == Linux-aarch64 ]]; then
           # FIXME: failing unittest(s)
           excludes+='|^std.internal.math.gammafunction'
           # FIXME: failing unittest(s) with enabled optimizations
diff --git a/.github/actions/helper-build-gdb/action.yml b/.github/actions/helper-build-gdb/action.yml
new file mode 100644
index 00000000000..8834231d5fa
--- /dev/null
+++ b/.github/actions/helper-build-gdb/action.yml
@@ -0,0 +1,47 @@
+name: Build gdb from source
+inputs:
+  arch:
+    required: true
+runs:
+  using: composite
+  steps:
+    - name: Pre-create user-owned directory /usr/local/share/gdb, required for cache restore
+      shell: bash
+      run: |
+        set -eux
+        sudo mkdir /usr/local/share/gdb
+        sudo chown $(id -u):$(id -g) /usr/local/share/gdb
+
+    - name: Try to restore from cache
+      uses: actions/cache@v4
+      with:
+        path: |
+          /usr/local/bin/gdb
+          /usr/local/share/gdb
+        key: gdb-${{ inputs.arch }}
+
+    - shell: bash
+      run: |
+        set -eux
+
+        if [[ -f /usr/local/bin/gdb ]]; then
+          echo "Already cached"
+          exit 0
+        fi
+
+        sudo apt-get -yq install libmpfr-dev
+
+        cd ..
+        curl -fL --retry 3 --max-time 60 -O https://mirrors.ocf.berkeley.edu/gnu/gdb/gdb-16.2.tar.xz
+        tar xf gdb-16.2.tar.xz
+
+        cd gdb-16.2
+        ./configure
+        make -j$(nproc)
+        sudo make install
+        cd ..
+
+        rm -rf gdb-16.2 gdb-16.2.tar.xz
+
+    - shell: bash
+      run: gdb --version
diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index ea649f5396b..05870b833f8 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -20,7 +20,7 @@ jobs:
         include:
 
           - job_name: Linux x86_64 multilib
-            os: ubuntu-20.04
+            os: ubuntu-22.04
             arch: x86_64
             # To improve portability of the generated binaries, link the C++ standard library statically.
             extra_cmake_flags: >-
@@ -34,8 +34,7 @@ jobs:
             with_pgo: true
 
           - job_name: Linux aarch64
-            os: ubuntu-22.04-arm # Ubuntu 20 not natively supported
-            container_image: ubuntu:20.04
+            os: ubuntu-22.04-arm
             arch: aarch64
             base_cmake_flags: >-
               -DCOMPILER_RT_LIBDIR_OS=aarch64-unknown-linux-gnu
@@ -152,6 +151,11 @@ jobs:
         with:
           llvm_version: ${{ matrix.llvm_version || env.LLVM_VERSION }}
           arch: ${{ matrix.arch }}
+      - name: 'Ubuntu 22: Build recent gdb from source' # see https://github.com/ldc-developers/ldc/issues/4389
+        if: startsWith(matrix.os, 'ubuntu-22.04')
+        uses: ./.github/actions/helper-build-gdb
+        with:
+          arch: ${{ matrix.arch }}
       - name: Build bootstrap LDC
         if: runner.os != 'macOS'
         uses: ./.github/actions/2-build-bootstrap
@@ -239,13 +243,13 @@ jobs:
         include:
 
           - job_name: Android armv7a
-            host_os: ubuntu-20.04
+            host_os: ubuntu-22.04
             os: android
             arch: armv7a
             android_x86_arch: i686
 
           - job_name: Android aarch64
-            host_os: ubuntu-20.04
+            host_os: ubuntu-22.04
             os: android
             arch: aarch64
             android_x86_arch: x86_64
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 9e88424f72e..ea3a1a2b34d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,6 +1,7 @@
 # LDC master
 
 #### Big news
+- The prebuilt (non-musl) Linux packages are now generated on Ubuntu 22.04; the minimum glibc version has accordingly been raised from v2.31 to v2.35. (#4893)
 - ldc2.conf: Arrays can now be appended to via the `~=` operator. (#4848, #4856)
 - New `--installWithSuffix` command-line option for the `ldc-build-runtime` tool, to simplify copying the libraries to an existing LDC installation. (#4870)