diff --git a/sycl/plugins/cuda/CMakeLists.txt b/sycl/plugins/cuda/CMakeLists.txt
index 448ea7e77f419..be94f687e12d0 100644
--- a/sycl/plugins/cuda/CMakeLists.txt
+++ b/sycl/plugins/cuda/CMakeLists.txt
@@ -43,7 +43,3 @@ install(TARGETS pi_cuda
   LIBRARY DESTINATION "lib${LLVM_LIBDIR_SUFFIX}" COMPONENT pi_cuda
   RUNTIME DESTINATION "bin" COMPONENT pi_cuda
 )
-
-# `sycl/source/CMakeLists.txt` adapted when SYCL_BUILD_PI_CUDA is defined:
-# target_link_libraries(sycl PUBLIC pi_cuda)
-# target_compile_definitions(sycl PUBLIC USE_PI_CUDA)
diff --git a/sycl/source/CMakeLists.txt b/sycl/source/CMakeLists.txt
index 7da8d346e8d3b..61486162b16d0 100644
--- a/sycl/source/CMakeLists.txt
+++ b/sycl/source/CMakeLists.txt
@@ -82,10 +82,6 @@ function(add_sycl_rt_library LIB_NAME)
       $<$<BOOL:${SYCL_BUILD_PI_CUDA}>:pi_cuda>
   )
 
-  target_compile_definitions(${LIB_OBJ_NAME}
-    PUBLIC
-      $<$<BOOL:${SYCL_BUILD_PI_CUDA}>:USE_PI_CUDA>)
-
   add_common_options(${LIB_NAME} ${LIB_OBJ_NAME})
 
   set_target_properties(${LIB_NAME} PROPERTIES
diff --git a/sycl/source/detail/context_impl.cpp b/sycl/source/detail/context_impl.cpp
index 1ef5929adb766..6d29e599addf6 100644
--- a/sycl/source/detail/context_impl.cpp
+++ b/sycl/source/detail/context_impl.cpp
@@ -45,7 +45,6 @@ context_impl::context_impl(const vector_class<cl::sycl::device> Devices,
 
   const auto Backend = getPlugin().getBackend();
   if (Backend == backend::cuda) {
-#if USE_PI_CUDA
     const bool UseCUDAPrimaryContext =
         MPropList.has_property<property::context::cuda::use_primary_context>();
     const pi_context_properties Props[] = {
@@ -55,10 +54,6 @@ context_impl::context_impl(const vector_class<cl::sycl::device> Devices,
 
     getPlugin().call<PiApiKind::piContextCreate>(
         Props, DeviceIds.size(), DeviceIds.data(), nullptr, nullptr, &MContext);
-#else
-    cl::sycl::detail::pi::die(
-        "CUDA support was not enabled at compilation time");
-#endif
   } else {
     getPlugin().call<PiApiKind::piContextCreate>(nullptr, DeviceIds.size(),
                                                  DeviceIds.data(), nullptr,