diff --git a/easybuild/easyconfigs/p/Python/Python-3.10.4-GCCcore-11.3.0.eb b/easybuild/easyconfigs/p/Python/Python-3.10.4-GCCcore-11.3.0.eb
index 1cfac838d2c..033fd05880f 100644
--- a/easybuild/easyconfigs/p/Python/Python-3.10.4-GCCcore-11.3.0.eb
+++ b/easybuild/easyconfigs/p/Python/Python-3.10.4-GCCcore-11.3.0.eb
@@ -99,14 +99,9 @@ exts_list = [
         'modulename': 'arff',
         'checksums': ['3220d0af6487c5aa71b47579be7ad1d94f3849ff1e224af3bf05ad49a0b5c4da'],
     }),
-    ('pycrypto', '2.6.1', {
-        'modulename': 'Crypto',
-        'patches': ['pycrypto-2.6.1_remove-usr-include.patch'],
-        'checksums': [
-            'f2ce1e989b272cfcb677616763e0a2e7ec659effa67a88aa92b3a65528f60a3c',  # pycrypto-2.6.1.tar.gz
-            # pycrypto-2.6.1_remove-usr-include.patch
-            '06c3d3bb290305e1360a023ea03f9281116c230de62382e6be9474996086712e',
-        ],
+    ('pycryptodome', '3.17', {
+        'modulename': 'Crypto.PublicKey.RSA',
+        'checksums': ['bce2e2d8e82fcf972005652371a3e8731956a0c1fbb719cc897943b3695ad91b'],
     }),
     ('ecdsa', '0.17.0', {
         'checksums': ['b9f500bb439e4153d0330610f5d26baaf18d17b8ced1bc54410d189385ea68aa'],
diff --git a/easybuild/easyconfigs/p/Python/Python-3.10.8-GCCcore-12.2.0.eb b/easybuild/easyconfigs/p/Python/Python-3.10.8-GCCcore-12.2.0.eb
index b919e01925b..c134f2d2796 100644
--- a/easybuild/easyconfigs/p/Python/Python-3.10.8-GCCcore-12.2.0.eb
+++ b/easybuild/easyconfigs/p/Python/Python-3.10.8-GCCcore-12.2.0.eb
@@ -101,14 +101,9 @@ exts_list = [
         'modulename': 'arff',
         'checksums': ['3220d0af6487c5aa71b47579be7ad1d94f3849ff1e224af3bf05ad49a0b5c4da'],
     }),
-    ('pycrypto', '2.6.1', {
-        'modulename': 'Crypto',
-        'patches': ['pycrypto-2.6.1_remove-usr-include.patch'],
-        'checksums': [
-            {'pycrypto-2.6.1.tar.gz': 'f2ce1e989b272cfcb677616763e0a2e7ec659effa67a88aa92b3a65528f60a3c'},
-            {'pycrypto-2.6.1_remove-usr-include.patch':
-             '06c3d3bb290305e1360a023ea03f9281116c230de62382e6be9474996086712e'},
-        ],
+    ('pycryptodome', '3.17', {
+        'modulename': 'Crypto.PublicKey.RSA',
+        'checksums': ['bce2e2d8e82fcf972005652371a3e8731956a0c1fbb719cc897943b3695ad91b'],
     }),
     ('ecdsa', '0.18.0', {
         'checksums': ['190348041559e21b22a1d65cee485282ca11a6f81d503fddb84d5017e9ed1e49'],