diff --git a/easybuild/easyblocks/m/mamba.py b/easybuild/easyblocks/m/mamba.py
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+++ b/easybuild/easyblocks/m/mamba.py
@@ -0,0 +1,49 @@
+##
+# Copyright 2009-2022 Ghent University
+#
+# This file is part of EasyBuild,
+# originally created by the HPC team of Ghent University (http://ugent.be/hpc/en),
+# with support of Ghent University (http://ugent.be/hpc),
+# the Flemish Supercomputer Centre (VSC) (https://www.vscentrum.be),
+# Flemish Research Foundation (FWO) (http://www.fwo.be/en)
+# and the Department of Economy, Science and Innovation (EWI) (http://www.ewi-vlaanderen.be/en).
+#
+# https://github.com/easybuilders/easybuild
+#
+# EasyBuild is free software: you can redistribute it and/or modify
+# it under the terms of the GNU General Public License as published by
+# the Free Software Foundation v2.
+#
+# EasyBuild is distributed in the hope that it will be useful,
+# but WITHOUT ANY WARRANTY; without even the implied warranty of
+# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+# GNU General Public License for more details.
+#
+# You should have received a copy of the GNU General Public License
+# along with EasyBuild.  If not, see <http://www.gnu.org/licenses/>.
+##
+"""
+EasyBuild support for building and installing Mamba, implemented as an easyblock
+
+@author: Caspar van Leeuwen (SURF)
+@author: Kenneth Hoste (HPC-UGent)
+"""
+
+import os
+
+from easybuild.easyblocks.a.anaconda import EB_Anaconda
+
+
+class EB_Mamba(EB_Anaconda):
+    """Support for building/installing Mamba."""
+
+    def sanity_check_step(self):
+        """
+        Custom sanity check for Mamba
+        """
+        custom_paths = {
+            'files': [os.path.join('bin', x) for x in ['2to3', 'conda', 'pydoc', 'python', 'mamba']],
+            'dirs': ['etc', 'lib', 'pkgs'],
+        }
+        # Directly call EB_Anaconda's super, as this sanity_check_step should _overwrite_ Anaconda's (not call it)
+        super(EB_Anaconda, self).sanity_check_step(custom_paths=custom_paths)