diff --git a/src/coreclr/tests/src/profiler/common/ProfilerTestRunner.cs b/src/coreclr/tests/src/profiler/common/ProfilerTestRunner.cs
index d425d4f544cf6e..6b5bb26e0fa59e 100644
--- a/src/coreclr/tests/src/profiler/common/ProfilerTestRunner.cs
+++ b/src/coreclr/tests/src/profiler/common/ProfilerTestRunner.cs
@@ -15,7 +15,7 @@ namespace Profiler.Tests
     public enum ProfileeOptions
     {
         None = 0,
-        DisableTieredCompilation,
+        OptimizationSensitive,
         NoStartupAttach
     }
 
@@ -41,10 +41,12 @@ public static int Run(string profileePath,
                 envVars.Add("CORECLR_PROFILER", "{" + profilerClsid + "}");
             }
 
-            if (profileeOptions.HasFlag(ProfileeOptions.DisableTieredCompilation))
+            if (profileeOptions.HasFlag(ProfileeOptions.OptimizationSensitive))
             {
-                Console.WriteLine("Disabling tiered compilation.");
+                Console.WriteLine("Disabling tiered compilation, jitstress, and minopts.");
                 envVars.Add("COMPlus_TieredCompilation", "0");
+                envVars.Add("COMPlus_JitStress", "0");
+                envVars.Add("COMPlus_JITMinOpts", "0");
             }
 
             string profilerPath = GetProfilerPath();
diff --git a/src/coreclr/tests/src/profiler/rejit/rejit.cs b/src/coreclr/tests/src/profiler/rejit/rejit.cs
index da7ff60f9f7316..ec5cddc1bf9f06 100644
--- a/src/coreclr/tests/src/profiler/rejit/rejit.cs
+++ b/src/coreclr/tests/src/profiler/rejit/rejit.cs
@@ -100,7 +100,7 @@ public static int Main(string[] args)
             return ProfilerTestRunner.Run(profileePath: System.Reflection.Assembly.GetExecutingAssembly().Location,
                                           testName: "ReJITWithInlining",
                                           profilerClsid: ReJitProfilerGuid,
-                                          profileeOptions: ProfileeOptions.DisableTieredCompilation);
+                                          profileeOptions: ProfileeOptions.OptimizationSensitive);
         }
     }
 }