diff --git a/crates/uv/src/commands/project/run.rs b/crates/uv/src/commands/project/run.rs
index 7921fee1be12a..e7266b49d8ea5 100644
--- a/crates/uv/src/commands/project/run.rs
+++ b/crates/uv/src/commands/project/run.rs
@@ -1181,7 +1181,7 @@ pub(crate) enum RunCommand {
     /// [zipapp]: <https://docs.python.org/3/library/zipapp.html>
     PythonZipapp(PathBuf, Vec<OsString>),
     /// Execute a `python` script provided via `stdin`.
-    PythonStdin(Vec<u8>),
+    PythonStdin(Vec<u8>, Vec<OsString>),
     /// Execute a Python script provided via a remote URL.
     PythonRemote(tempfile::NamedTempFile, Vec<OsString>),
     /// Execute an external command.
@@ -1208,7 +1208,7 @@ impl RunCommand {
                     Cow::Borrowed("python")
                 }
             }
-            Self::PythonStdin(_) => Cow::Borrowed("python -c"),
+            Self::PythonStdin(..) => Cow::Borrowed("python -c"),
             Self::External(executable, _) => executable.to_string_lossy(),
         }
     }
@@ -1261,7 +1261,7 @@ impl RunCommand {
                 process.args(args);
                 process
             }
-            Self::PythonStdin(script) => {
+            Self::PythonStdin(script, args) => {
                 let mut process = Command::new(interpreter.sys_executable());
                 process.arg("-c");
 
@@ -1276,6 +1276,7 @@ impl RunCommand {
                     let script = String::from_utf8(script.clone()).expect("script is valid UTF-8");
                     process.arg(script);
                 }
+                process.args(args);
 
                 process
             }
@@ -1414,7 +1415,7 @@ impl RunCommand {
         if target.eq_ignore_ascii_case("-") {
             let mut buf = Vec::with_capacity(1024);
             std::io::stdin().read_to_end(&mut buf)?;
-            Ok(Self::PythonStdin(buf))
+            Ok(Self::PythonStdin(buf, args.to_vec()))
         } else if target.eq_ignore_ascii_case("python") {
             Ok(Self::Python(args.to_vec()))
         } else if target_path
diff --git a/crates/uv/src/lib.rs b/crates/uv/src/lib.rs
index 9c8d87466c993..17a2e8581e8c1 100644
--- a/crates/uv/src/lib.rs
+++ b/crates/uv/src/lib.rs
@@ -175,7 +175,7 @@ async fn run(mut cli: Cli) -> Result<ExitStatus> {
                 Some(RunCommand::PythonRemote(script, _)) => {
                     Pep723Metadata::read(&script).await?.map(Pep723Item::Remote)
                 }
-                Some(RunCommand::PythonStdin(contents)) => {
+                Some(RunCommand::PythonStdin(contents, _)) => {
                     Pep723Metadata::parse(contents)?.map(Pep723Item::Stdin)
                 }
                 _ => None,
diff --git a/crates/uv/tests/it/run.rs b/crates/uv/tests/it/run.rs
index 8feecd781944a..3fd44aa22ef12 100644
--- a/crates/uv/tests/it/run.rs
+++ b/crates/uv/tests/it/run.rs
@@ -2493,6 +2493,20 @@ fn run_zipapp() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn run_stdin_args() {
+    let context = TestContext::new("3.12");
+
+    uv_snapshot!(context.filters(), context.run().arg("python").arg("-c").arg("import sys; print(sys.argv)").arg("foo").arg("bar"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    ['-c', 'foo', 'bar']
+
+    ----- stderr -----
+    "###);
+}
+
 /// Run a module equivalent to `python -m foo`.
 #[test]
 fn run_module() {