diff --git a/appengine/flexible/scipy/.gitignore b/appengine/flexible/scipy/.gitignore
new file mode 100644
index 00000000000..de724cf6213
--- /dev/null
+++ b/appengine/flexible/scipy/.gitignore
@@ -0,0 +1 @@
+assets/resized_google_logo.jpg
diff --git a/appengine/flexible/scipy/README.md b/appengine/flexible/scipy/README.md
new file mode 100644
index 00000000000..4f0df036549
--- /dev/null
+++ b/appengine/flexible/scipy/README.md
@@ -0,0 +1,4 @@
+# SciPy on App Engine Flexible
+
+This sample demonstrates how to use SciPy to resize an image on App Engine Flexible.
+
diff --git a/appengine/flexible/scipy/app.yaml b/appengine/flexible/scipy/app.yaml
new file mode 100644
index 00000000000..00539c11722
--- /dev/null
+++ b/appengine/flexible/scipy/app.yaml
@@ -0,0 +1,6 @@
+runtime: python
+vm: true
+entrypoint: gunicorn -b :$PORT main:app
+
+runtime_config:
+  python_version: 3
diff --git a/appengine/flexible/scipy/assets/google_logo.jpg b/appengine/flexible/scipy/assets/google_logo.jpg
new file mode 100644
index 00000000000..5538eaed2bd
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diff --git a/appengine/flexible/scipy/assets/resized_google_logo.jpg b/appengine/flexible/scipy/assets/resized_google_logo.jpg
new file mode 100644
index 00000000000..971fb566e15
Binary files /dev/null and b/appengine/flexible/scipy/assets/resized_google_logo.jpg differ
diff --git a/appengine/flexible/scipy/fixtures/assets/resized_google_logo.jpg b/appengine/flexible/scipy/fixtures/assets/resized_google_logo.jpg
new file mode 100644
index 00000000000..971fb566e15
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diff --git a/appengine/flexible/scipy/main.py b/appengine/flexible/scipy/main.py
new file mode 100644
index 00000000000..612042c19de
--- /dev/null
+++ b/appengine/flexible/scipy/main.py
@@ -0,0 +1,52 @@
+# Copyright 2016 Google Inc. All Rights Reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import logging
+import os
+
+from flask import Flask
+import scipy.misc
+
+app = Flask(__name__)
+
+
+# [START scipy]
+@app.route('/')
+def resize():
+    """Demonstrates using scipy to resize an image."""
+    app_path = os.path.dirname(os.path.realpath(__file__))
+    image_path = os.path.join(app_path, 'assets/google_logo.jpg')
+    img = scipy.misc.imread(image_path)
+    img_tinted = scipy.misc.imresize(img, (300, 300))
+    output_image_path = os.path.join(
+        app_path, 'assets/resized_google_logo.jpg')
+    # Write the tinted image back to disk
+    scipy.misc.imsave(output_image_path, img_tinted)
+    return "Image resized."
+# [END scipy]
+
+
+@app.errorhandler(500)
+def server_error(e):
+    logging.exception('An error occurred during a request.')
+    return """
+    An internal error occurred: <pre>{}</pre>
+    See logs for full stacktrace.
+    """.format(e), 500
+
+
+if __name__ == '__main__':
+    # This is used when running locally. Gunicorn is used to run the
+    # application on Google App Engine. See entrypoint in app.yaml.
+    app.run(host='127.0.0.1', port=8080, debug=True)
diff --git a/appengine/flexible/scipy/main_test.py b/appengine/flexible/scipy/main_test.py
new file mode 100644
index 00000000000..7765f3bf450
--- /dev/null
+++ b/appengine/flexible/scipy/main_test.py
@@ -0,0 +1,35 @@
+# Copyright 2016 Google Inc. All Rights Reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import filecmp
+import os
+
+import main
+
+
+def test_index():
+    main.app.testing = True
+    client = main.app.test_client()
+    test_path = os.path.dirname(os.path.realpath(__file__))
+    asset_path = os.path.join(
+        test_path, 'assets/resized_google_logo.jpg')
+    fixtured_path = os.path.join(
+        test_path, 'fixtures/assets/resized_google_logo.jpg')
+    try:
+        os.remove(asset_path)
+    except OSError:
+        pass  # if doesn't exist
+    r = client.get('/')
+    assert filecmp.cmp(asset_path, fixtured_path)
+    assert r.status_code == 200
diff --git a/appengine/flexible/scipy/requirements.txt b/appengine/flexible/scipy/requirements.txt
new file mode 100644
index 00000000000..ed88c85aa90
--- /dev/null
+++ b/appengine/flexible/scipy/requirements.txt
@@ -0,0 +1,4 @@
+Flask==0.11.1
+gunicorn==19.6.0
+scipy==0.18.0
+Pillow==3.3.1
diff --git a/requirements-dev.txt b/requirements-dev.txt
index ff23415e98a..d6141d603ff 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -40,6 +40,7 @@ requests==2.11.1
 requests[security]==2.11.1
 responses==0.5.1
 rsa==3.4.2
+scipy==0.18.0
 sendgrid==3.2.10
 simplejson==3.8.2
 six==1.10.0